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. 2010 Dec 13;286(5):3177–3184. doi: 10.1074/jbc.R110.179325

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© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 3. — GRα isoforms generated by alternative translation initiation and sites of post-translational modification. Initiation of translation from eight different AUG start codons in a single GRα mRNA generates receptor isoforms with progressively shorter NTDs. Approximate locations of the AUG start codons in the exon 2 sequences of the GRα mRNA are designated by asterisks. The initiator methionines, AF1 region (amino acids 77–262), and sites of post-translational modifications (phosphorylation (P), sumoylation (S), ubiquitination (U), and acetylation (A)) are indicated for the human GRα isoforms. H, hinge region.