TABLE 2.

PB EC₅₀ values from wild-type (WT) and mutant GABA_ARs

Values are mean ± S.E. from n experiments. Ranges in I_PBmax and I_GABAmax currents elicited from oocytes expressing WT or mutant GABA_ARs are indicated. I_PBmax/I_GABAmax ratios from the same oocyte are mean ± S.E. from n experiments. Mutants indicated with ‘VV’ have a valine mutation at both sites 1 and 2.

Receptor	EC50	nH	n	IPBmax	IGABAmax	IPBmax/IGABAmax	n
	μm			μA
WT	275.35 ± 51.58	2.77 ± 0.41	4	4.14–9.32	6.93–15.58	0.57 ± 0.06	7
αβA134Fγ	1,171.33 ± 69.00a	2.00 ± 0.32	3	0.96–6.39	0.67–4.16	1.57 ± 0.19b	4
αβγA149F	608.93 ± 22.21a	3.70 ± 0.41	3	4.84–6.49	8.39–11.61	0.52 ± 0.07	6
αA136FβA134Fγ	1,424.33 ± 53.57a	2.06 ± 0.16	3	0.52–2.29	0.11–0.60	4.62 ± 0.79a	5
αA136FβA134FγA149F	840.00 ± 71.29a	2.50 ± 0.05	3	1.73–3.38	1.96–5.00	0.74 ± 0.10	5
αA136VβA134Vγ	243.70 ± 11.47	2.65 ± 0.11	3	6.06–15.03	4.73–11.85	1.30 ± 0.03b	4
α'VV'β'VV'γ'VV'	1,744.66 ± 120.66a	2.23 ± 0.32	3	0.81–1.64	0.20–0.27	5.17 ± 1.07a	4

^a p < 0.01, values statistically different from WT.

^b p < 0.05, values statistically different from WT.