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The UbQ-binding Ser68 in the QP site of CII is important for the effect of MitoVE11S. B9Ras-SDHC (WT), B9Ras-SDHCS68A (S68A), or B9Ras-SDHCS68L cells (S68L) were exposed to MitoVE11S at 2 μm for the times shown and assessed for ROS accumulation (A) and apoptosis levels (B). The data are mean ± S.D. (error bars) (n = 3). *, significant difference (p < 0.05) between MitoVE11S-treated B9Ras cells stably transfected with WT SDHC or with S68A or C68L mutant SDHC.
