FIGURE 1.

COG112 improves clinical parameters in C. rodentium-induced colitis in mice. 7-week-old C57BL/6J mice were orally inoculated with 1 × 10⁸ CFU of C. rodentium or broth at day 0. COG112 (1 mg/kg) or PBS was injected intraperitoneal each day. A, animal mortality is presented as % survival, p = 0.0215. B, body weights of the mice were measured daily and are presented as a percentage of their initial weight. *, p < 0.05; **, p < 0.01; ***, p < 0.001 versus C. rodentium-infected mice. C, upon sacrifice on day 12, colons were removed, cleaned, and weighed. Colon weights are presented as % of mouse body weight on the day of sacrifice. ***, p < 0.001 versus control; §§, p < 0.01 versus C. rodentium-infected. In A–C, n = 11 for control, n = 9 for control + COG112, n = 30 for C. rodentium infected and for C. rodentium + COG112.