Table 1.
Statistical results for all figures
| Figure(s) | Dependent variable | Factor(s) | Results |
|---|---|---|---|
| 1C | Rewards earned | Drug dose | 0 s ITI: F(6,7) = 2.4, p = 0.04, n = 8 rats |
| 3 s ITI: F(6,6) = 4.2, p = 0.003, n = 7 | |||
| 10 s ITI: F(6,7) = 5.5, p < 0.001, n = 8 | |||
| 20 s ITI: F(6,6) = 11.5, p < 0.001, n = 7 | |||
| 1D,E, S2A | Log latency between events (cue-lever press, lever press-entry, consummatory) | Interval, drug dose | Interaction interval × drug dose: |
| 0 s ITI: F(12,7) = 0.8, p = 0.7 | |||
| 3 s ITI: F(12,6) = 2.5, p = 0.008 | |||
| 10 s ITI: F(12,6) = 2.6, p = 0.006 | |||
| 20 s ITI: F(12,6) = 11.3, p < 0.001 | |||
| 1F | Rewards earned | Drug dose | 0 s ITI core: F(6,7) = 1.6, p = 0.18, n = 8 |
| 0 s ITI shell: F(6,7) = 1.5, p = 0.2, n = 8 | |||
| 20 s ITI core: F(6,7) = 6.8, p < 0.001, n = 8 | |||
| 20 s ITI shell: F(6,7) = 5.7, p < 0.001, n = 8 | |||
| 1G,H, S2B | Log latency between events (cue-lever press, lever press-entry, consummatory) | Interval, drug dose | Interaction interval × drug dose: |
| 0 s ITI core: F(12,7) = 1.0, p = 0.5 | |||
| 0 s ITI shell: F(12,6) = 1.6, p = 0.1 | |||
| 20 s ITI core: F(12,4) = 3.3, p = 0.001 | |||
| 20 s ITI shell: F(12,7) = 4.9, p < 0.001 | |||
| 2A, inset | Log latency between receptacle exit and lever press | ITI | Non-repeated-measures ANOVA: |
| F(3,58) = 320, p < 0.001 | |||
| 2B, inset | Log latency between lever press and receptacle entry | ITI | Non-repeated-measures ANOVA: |
| F(3,58) = 6.4, p < 0.001 | |||
| 2C | % of trials | Drug dose | Near lever: F(2,5) = 7.8, p = 0.016, n = 6 rats |
| Far from lever:: F(2,5) = 11.8, p = 0.006 | |||
| 2D | Log latency between cue onset and lever press | Location, drug dose | Location: F(1,4) = 47.9, p = 0.002 |
| Drug dose: F(2,4) = 5.0, p = 0.04 | |||
| Interaction location × drug dose: F(2,4) = 0.3, p = 0.7 | |||
| 3A | % of trials | Drug dose | Task activity: F(2,5) = 9.3, p = 0.011, n = 6 rats |
| Immobility: F(2,5) = 13.8, p = 0.004 | |||
| Locomotion: F(2,5) = 0.9, p = 0.45 | |||
| Grooming: F(2,5) = 1.5, p = 0.29 | |||
| 3B | Log latency between cue onset and lever press | Action at cue onset, drug dose | Action at cue onset: F(3,4) =71.6, p < 0.001 |
| Drug dose: F(2,4) = 6.1, p = 0.02 | |||
| Interaction action × drug dose: F(6,4) = 0.4, p = 0.9 | |||
| 3B, inset | Log latency between cue onset and lever press | Drug dose | Lever pressing: F(2,5) = 10.4, p = 0.006 |
| 3C | % of trials press | Drug dose | Immediate response: F(2,5) = 14.0, p = 0.004 |
| Immobility: F(2,5) = 8.1, p = 0.015 | |||
| Locomotion: F(2,5) = 6.0, p = 0.03 | |||
| Grooming: F(2,5) = 1.5, p = 0.28 | |||
| 3D | Log latency between cue onset and lever press | Action after cue onset (comparison with Immediate Response), drug dose | Immobility vs immediate response: |
| Action: F(1,4) = 208.6, p < 0.001 | |||
| Drug dose: F(2,4) = 11.5, p = 0.003 | |||
| Interaction action × drug dose: F(2,4) = 2.2, p = 0.2 | |||
| Locomotion vs immediate response: | |||
| Action: F(1,4) = 201.1, p < 0.001 | |||
| Drug dose: F(2,4) = 16.5, p < 0.001 | |||
| Interaction action × drug dose: F(2,4) = 3.4, p = 0.1 | |||
| Grooming vs immediate response: | |||
| Action: F(1,3) = 77.9, p = 0.003 | |||
| Drug dose: F(2,3) = 11.3, p = 0.009 | |||
| Interaction action × drug dose: F(2,3) = 3.7, p = 0.09 | |||
| 4C | Cue response ratio | Location, drug dose | DS: |
| Location: F(2,4) = 16.8, p = 0.001 | |||
| Drug dose: F(6,4) = 9.5, p < 0.001 | |||
| Interaction location × drug dose: F(12,4) = 1.0, p = 0.4 | |||
| NS: all main & interaction F > 0.2 | |||
| n = 6 rats | |||
| 4D | Movement velocity | Movement type, drug dose | Movement type: F(3,4) = 12.2, p < 0.001 |
| Drug dose: F(6,4) = 1.6, p = 0.2 | |||
| Interaction movement type × drug dose: | |||
| F(18,4) = 1.4, p = 0.2 | |||
| (post hoc tests show post-DS movements resulting in lever press to be faster than each other type of movement, irrespective of drug dose) | |||
| 4E | First movement log latency | Cue, drug dose | Interaction cue × drug dose: |
| F(6,4) = 4.2, p = 0.005 | |||
| 5C | Rewards earned | Drug dose | Cue 1: F(6,6) = 0.7, p = 0.7, n = 7 rats |
| Cue 2: F(6,6) = 0.7, p = 0.7 | |||
| 5D | Log latency to reach receptacles 1 and 2 | Drug dose | Cue 1–receptacle 1 entry latency: F(6,6) = 2.3, p = 0.06 |
| Cue 2–receptacle 2 entry latency: F(6,6) = 7.1, p < 0.001 | |||
| 5E | % of trials | Drug dose | F(6,6) = 0.2, p = 0.97 |
| 5F | % of trials | Drug dose | F(6,6) = 1.5, p = 0.2 |
| 5G | Log latency to respond to cue 3 | Drug dose | Cue 3–receptacle 2 exit latency: F(6,6) = 1.0, p = 0.5 |
| Receptacle 2 exit–receptacle 1 entry latency: F(6,6) = 1.6, p = 0.2 | |||
| 7C | Log latency between events | Interval, drug | Interaction interval × drug: |
| F(2,7) = 5.7, p = 0.02, n = 9 rats | |||
| 7E, inset | % of trials | Drug | F(2,8) = 0.7, p = 0.5 |
| 7F | Log latency between lever presses | Distance traveled, drug dose | Interaction distance traveled × drug: |
| F(2,7) = 4.4, p = 0.03 | |||
| 7G | Velocity of last movement before lever press | Interval, drug | Interval: F(1,7) = 6.5, p = 0.04 |
| Drug: F(1,7) = 3.5, p = 0.06 | |||
| Interaction interval × drug: | |||
| F(2,7) = 0.3, p = 0.7 |
Unless otherwise noted, all tests are repeated-measures ANOVA with one or two factors.