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. Author manuscript; available in PMC: 2012 Feb 23.
Published in final edited form as: Neuroscience. 2010 Dec 1;175:315–327. doi: 10.1016/j.neuroscience.2010.11.057

Figure 4. Amitriptyline-induced analgesia in combined NET/SERT KO mice.

Figure 4

The data represent analgesic responses to amitriptyline (0–40 mg/kg IP) in NET/SERT KO mice for supraspinal analgesia in the hot-plate test (A) and spinal analgesia in the tail-flick test (B). In the hot-plate test all genotypes except NET −/− SERT +/− and NET −/− SERT −/− had significant amitriptyline analgesia. NET KO dose-dependently enhanced hot-plate analgesia. In the tail-flick test all genotypes except NET−/− SERT −/− had significant amitriptyline analgesia. As discussed in the text because of the exclusion of NET subjects because of high baseline analgesia these results must be considered tentatively.