Table 2.

Radiation Therapy Oncology Group (RTOG)/European Organisation for Research and Treatment of Cancer (EORTC) late radiation morbidity scoring scheme [14]

	Grade 1	Grade 2	Grade 3	Grade 4
Bladder	Slight atrophy; microscopic hematuria	Moderate frequency/telangiectasia; intermittent hematuria	Severe frequency/telangiectasia/dysuria; frequent hematuria	Necrosis; contracted (capacity <100 ml); severe hemorrhagic cystitis
Bone	Asymptomatic; reduced density	Moderate pain; irregular sclerosis	Severe pain; dense sclerosis	Necrosis/spontaneous fracture
Lung	Asymptomatic or mild symptoms; slight radiographic appearances	Moderate symptomatic fibrosis (cough); patchy radiographic appearances	Severe symptomatic fibrosis; dense radiographic changes	Respiratory insufficiency; ventilation
Mucous membrane/skin	Slight atrophy	Mild atrophy and telangiectasia	Marked atrophy, severe telangiectasia	Ulceration
Small/large intestine	Mild diarrhea/cramping/ discharge or bleeding	Moderate diarrhea and colic; excessive mucus	Obstruction or bleeding requiring surgery	Necrosis/perforation/fistula