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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2010 Aug 5;30(10):1933–1939. doi: 10.1161/ATVBAHA.110.206342

Figure 1.

Figure 1

High-resolution in vivo fluorescence molecular imaging of multiple inflammatory targets in murine carotid atheromata. IVFM of carotid arteries revealed (A) discrete plaque-specific MMP and macrophage activity in apoE−/− mice in contrast to (B) normal carotid vessels of age- and sex-matched C57BL/6J mice. (C) The in vivo plaque MMP target-to-background ratio (TBR) in apoE−/− mice was 55% higher than in C57BL/6J mice (1.9±0.1 vs. 1.2±0.1; P<0.001). (D) Similarly, the in vivo plaque macrophage TBR was 110% greater in apoE−/− mice (2.4±0.1 vs. 1.1±0.1, P<0.001). Images within each channel were windowed and processed identically. Mac=macrophage.