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. Author manuscript; available in PMC: 2011 Jan 28.
Published in final edited form as: Breast Cancer Res Treat. 2007 Sep 13;110(2):357–366. doi: 10.1007/s10549-007-9717-2

Fig. 1.

Fig. 1

Genomic structure, locations of common SNPs and possible binding sites in the H2AFX gene. Numbering is based on cDNA sequence (GenBank DQ015918). The nucleotide 5′ of the ATG-translation initiation codon is −1, +1 corresponds to the A of the ATG translation initiation codon in the reference sequence. The −676T > G locus was in complete LD with −1187T > C, thus, four SNPs (−1654A > G, −1420G > A, −1187T > C, and 1057C > T) were selected as the tagging SNPs. Bioinformatics analysis for the promoter SNPs: −1654G but not −1654A is the binding site for oncogene c-Jun; −1420G but not −1420A is a binging site fro insulin activator factor; −1187T but not −1187C has a binding site for progesterone receptor; and −676T (which completely linked with −1187T) but not −676G has a binding site for transcription factor PU.1