Table 2.
H2AFX genotypes and allele frequencies and logistic regression analysis for associations with risk of breast cancer
| Genotypesa | Cases n (%) | Controls n (%) | Pb | OR (95% CI)c |
|---|---|---|---|---|
| Total number of subjects | 467 | 488 | ||
| Total number of alleles | 934 | 976 | ||
| −1654A>G | ||||
| AA | 147 (31.5) | 220 (45.1) | <0.0001 | 1.00 (ref.) |
| AG | 236 (50.5) | 218 (44.7) | 1.63 (1.23–2.15) | |
| GG | 84 (18.0) | 50 (10.2) | 2.55 (1.69–3.84) | |
| P trend | <0.0001 | |||
| AG + GG | 320 (68.5) | 268 (54.9) | 1.80 (1.38–2.34) | |
| G allele | 0.433 | 0.326 | <0.0001 | |
| −1420G>A | ||||
| GG | 143 (30.6) | 186 (38.1) | 0.018 | 1.00 (ref.) |
| GA | 236 (50.5) | 235 (48.2) | 1.31 (0.98–1.74) | |
| AA | 88 (18.9) | 67 (13.7) | 1.72 (1.17–2.53) | |
| P trend | 0.005 | |||
| GA + AA | 324 (69.4) | 302 (61.9) | 1.40 (1.07–1.83) | |
| A allele | 0.441 | 0.378 | 0.005 | |
| −1187T>C | ||||
| TT | 141 (30.2) | 204 (41.8) | 0.001 | 1.00 (ref.) |
| TC | 252 (54.0) | 219 (44.9) | 1.66 (1.25–2.19) | |
| CC | 74 (15.8) | 65 (13.3) | 1.63 (1.10–2.43) | |
| P trend | 0.002 | |||
| TC + CC | 326 (69.8) | 284 (58.2) | 1.65 (1.26–2.16) | |
| C allele | 0.428 | 0.358 | 0.002 | |
| 1057C>T | ||||
| CC | 187 (40.0) | 206 (42.2) | 0.230 | 1.00 (ref.) |
| CT | 225 (48.2) | 211 (43.2) | 1.18 (0.90–1.54) | |
| TT | 55 (11.8) | 71 (14.6) | 0.86 (0.57–1.29) | |
| P trend | 0.917 | |||
| CT + TT | 280 (60.0) | 282 (57.8) | 1.10 (0.85–1.42) | |
| T allele | 0.359 | 0.362 | 0.891 |
a
The observed genotype frequency among the control subjects was in agreement with the Hardy–Weinberg equilibrium (p2 + 2pq + q2 = 1) (χ2 = 0.14, P = 0.710 for −1654A>G; χ2 = 0.28, P = 0.596 for −1420G>A; χ2 = 0.26, P = 0.608 for −1187T>C and χ2 = 1.97, P = 0.160 for 1057C>T)
b
Two-sided χ2 test for the distribution of either genotype or allele frequency
c
Adjusted for age, smoking, and alcohol use in logistic regression models