TABLE 1.
Notch pathway genes and mutants characterized in this study
| Gene | Genetic lesion | Type | ptcGAL4 | ptcGAL4 smo RNAi | Source |
|---|---|---|---|---|---|
| N | Df(1)RR62 | Del | ND | E | BDSC |
| N | Df(1)N-8 | Del | ND | E | BDSC |
| N | Df(1)N-264-105 | Del | ND | E | BDSC |
| N | N55e11/+ | Null | ND | E | BDSC |
| N | Nfa-1 | Mut | NC | E | BDSC |
| N | Nnd-0 | Mut | NC | E | BDSC |
| N | NNIG.3936R-2 | RNAi | Fused | E | NIG |
| N | UAS-N14E | RNAi | NC | L | BDSC |
| N | UAS-NFLN | Ect exp | VT | S | A. Martinez Arias (Cambridge University). |
| psn | P{GD4624}v43082 | RNAi | Fused | E | VDRC |
| psn | P{GD4624}v43083 | RNAi | Fused | E | VDRC |
| Su(H) | Su(H)NIG.3497R-1 | RNAi | 3/4− | E | NIG |
| Su(H) | Su(H)NIG.3497R-3 | RNAi | 3/4− | E | NIG |
| E(spl) | Df(3R)Espl3 | Del | ND | E | BDSC |
| E(spl) | Df(3R)BSC751 | Del | ND | E | BDSC |
| E(spl) | Df(3R)Espl1 | Del | ND | E | BDSC |
| E(spl) | Df(3R)BSC495 | Del | ND | E | BDSC |
| E(spl) | Df(3R)Exel6204 | Del | ND | E | BDSC |
| E(spl) | UAS-HLH-m-Δ | Ect exp | 3/4++ | S | BDSC |
| E(spl) | UAS-HLH-m8 | Ect exp | 3/4++ | S | BDSC |
| vn | vnNIG.10491R-1 | RNAi | 3/4− | E | NIG |
| Su(dx) | Su(dx)NIG.4244R-1 | RNAi | ACV− | S | NIG |
Deletions, mutations, and RNAi transgenes are indicated as Del, Mut, and RNAi, respectively. Wing phenotypes with ptcGAL4 and ptcGAL4 smo RNAi at 29° are described. Del, deletion; Mut, hypomorphic mutation; Ect exp, ectopic expression; NC, no change; ND, not determined; 3/4−, reduction in distance between veins 3 and 4; 3/4++, increased distance between veins 3 and 4; Fused, fusion of veins 3 and 4; E, enhanced; S, suppressed; L, lethal; VT, vein thickening; BDSC, Bloomington Drosophila Stock Center (USA); NIG, National Institute of Genetics (Mishima, Japan); VDRC, Vienna Drosophila RNAi Center.