Table 3.
Association of ANGPTL4 polymorphisms with risk of brain arteriovenous malformation
| Genotype | Case |
Controls |
OR (95% CI)a | OR (95% CI)b | ||
|---|---|---|---|---|---|---|
| n | % | n | % | |||
| rs2278236 | ||||||
| TT | 70 | 32.4 | 68 | 27.6 | 1.00 (reference) | 1.00 (reference) |
| CT | 112 | 51.9 | 126 | 51.2 | 0.86 (0.57–1.31) | 0.96 (0.62–1.51) |
| CC | 34 | 15.7 | 52 | 21.1 | 0.64 (0.37–1.10) | 0.73 (0.41–1.30) |
| Any C versus TT | 146 | 67.6 | 178 | 72.4 | 0.80 (0.54–1.19)c | 0.90 (0.58–1.38)c |
| rs1044250 | ||||||
| CC | 100 | 46.3 | 112 | 45.5 | 1.00 (reference) | 1.00 (reference) |
| CT | 90 | 41.7 | 110 | 44.7 | 0.92 (0.62–1.35) | 0.85 (0.57–1.29) |
| TT | 26 | 12.0 | 24 | 9.8 | 1.21 (0.66–2.25) | 1.23 (0.63–2.41) |
| Any T versus CC | 116 | 53.7 | 134 | 54.5 | 1.00 (0.67–1.40)c | 0.92 (0.62–1.35)c |
| rs11672433 | ||||||
| GG | 143 | 66.2 | 190 | 77.2 | 1.00 (reference) | 1.00 (reference) |
| AG | 63 | 29.2 | 50 | 20.3 | 1.67 (1.09–2.57) | 1.48 (0.93–2.33) |
| AA | 10 | 4.6 | 6 | 2.4 | 2.21 (0.79–6.23) | 2.25 (0.77–6.64) |
| Any A versus GG | 73 | 33.8 | 56 | 22.8 | 1.73 (1.15–2.61)c | 1.56 (1.01–2.41)c |
| rs1808536 | ||||||
| GG | 153 | 70.8 | 181 | 73.6 | 1.00 (reference) | 1.00 (reference) |
| AG | 57 | 26.4 | 64 | 26.0 | 1.05 (0.70–1.60) | 1.31 (0.84–2.04) |
| AA | 6 | 2.8 | 1 | 0.4 | N/Ad | N/Ad |
| Any A versus GG | 63 | 29.2 | 65 | 26.4 | 1.15 (0.76–1.72)c | 1.42 (0.92–2.20)c |
a
Estimated from logistic regression model assuming a co-dominant inheritance model.
b
Additionally adjusted for age at diagnosis and gender.
c
Estimated from logistic regression model assuming a dominant inheritance model.
d
N/A due to small sample size.