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Loss of the analgesic effect of LY379268 in mGlu3-/- mice following repeated dosing. Vehicle or LY379268 (3 mg/kg, i.p.) were injected for 4 days every 24 hours in mGlu3-/- mice. On day 5 vehicle or LY379268 were administered 30 min before formalin injection. Data represent the mean ± S.E.M. of 8 to 12 mice. p > 0.3 vs vehicle group (t-test).
