Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2011 Jan 11;10:4. doi: 10.1186/1475-2875-10-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright ©2011 Torrentino-Madamet et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Gene networks involved in the metabolic adaptation to hyperoxia in tightly synchronized P. falciparum cultures. Using PS 6.0™ software and microarray expression data, gene networks were built and genes modulated in response to hyperoxia are represented. (A) Representation of metabolic interrelations related to adaptative hyperoxia exposure. Energetic metabolism: aspartate carbamoyltransferase (P13_0240), carbamoyl-phosphate synthetase (PF13_0044), glutamine-fructose-6-phosphate transaminase (PF10_0245), glucose-6-phosphate dehydrogenase (PF14_0511), acetyl-CoA synthetase (PFF1350c), gapdh (PF14_0598) - Signal transduction: regulatory sub-unit of cAMP-dependent protein kinase (PFL1110c), catalytic sub-unit of cAMP-dependent protein kinase (PFI1685w), ser thr protein kinase (PF13_0085) - Translation: citrate synthase (PF10_0218), translation elongation factor 1 alpha 1 (PF13_0305), proteasome 26S subunit (MAL13P1.343), dihydrolipoamide dehydrogenase (PFL1550w), translation elongation factor 2 (PF14_0486), adaptor-related protein complex 1 (PF13_0062), polymerase RNA I (PF11_0358) - DNA repair: DNA primase (PF14_0366 and PFI0530c), rpa1 (PFI0235w) - Protein folding: ferredoxin reductase (PF11_0407), Hsp10 (PFL0740c), Hsp60 (PF10_0153), Hsp70 (PF11_0351 and PF08_0054), Hsp90 (PFL1070c and PF07_0029), prohibitin (PF08_0006), DnaJ (PFF1415c). (B) Representation of ATP-dependent gene sub-networks altered in hyperoxic conditions. V-type ATPase: V-type ATPase putative (MAL13P1.271), vacuolar ATP synthase subunit h putative (PF13_0034), vacuolar ATP synthetase putative (PFE0965c), vacuolar ATP synthase subunit F putative (PF11_0412), vacuolar ATP synthase subunit D putative (PF13_0227), vacuolar ATP synthase catalytic subunit a (PF13_0065) - Mitochondrial ATP synthase F1: ATP synthase subunit putative (PF14_0615), mitochondrial ATP synthase F1 epsilon subunit (MAL7P1.75), mitochondrial ATP synthase F1 alpha subunit putative (PFB0795w). Red and blue colors correspond respectively to up- and down-regulated genes compared between hyperoxic to normoxic conditions.