Figure 4.

Alterations of the P. falciparum proteome under hyperoxic exposure. The proteins from P. falciparum parasites cultivated under normoxic (A) or hyperoxic (B) conditions were labelled with Cy3 and Cy5, respectively, and separated by 2-DE using a 10% homogeneous SDS polyacrylamide gel with a pH range from 3 to 10. As determined by DeCyder software, protein spots that were down- (A) or up- (B) regulated following hyperoxic exposure (|FC|≥1.5, p ≤ 0.05) are marked with master numbers (Table 2 and Additional file 5). Bold and italic numbers correspond, respectively, to proteins identified from P. falciparum and Homo sapiens. Areas of gels containing a high density of spots down- and up-modulated are enlarged.