Table 1.
Biological functions perturbed following hyperoxia exposure on P. falciparum
| Functional groupa | Number of entitiesb | p-valuec |
|---|---|---|
| GPI anchor biosynthesis | 29 | 0.0006 |
| DNA repair | 15 | 0.0072 |
| Vacuolar acidification | 11 | 0.0255 |
| Actin filament organization | 12 | 0.0296 |
| Nucleosome assembly | 12 | 0.0490 |
| Regulation of cell shape | 6 | 0.0519 |
| Leading strand elongation | 10 | 0.0533 |
| Lysosomal H+ import | 26 | 0.0589 |
| Response to oxidative stress | 17 | 0.0799 |
aGene Set Enrichment Analysis (GSEA) using the Mann-Whitney-U-test enrichment algorithm in PathwayStudio software indicated functional groups significantly altered (p < 0.08). For each functional group, the bnumber of genes included and corresponding cp-values are listed.