Table 3. The differently expressed proteins identified based on single peptides in CD4+ T cells between active VKH patients and normal individuals.
| Genesymbol | Swiss-prot accession No. | Identified proteins | Expression Ratioa (VKH:NC) | Xcorrb | t-test p | MH+(Da) | Mass stdev(Da) | Identified Peptide |
| Up-regulated in VKH | ||||||||
| ITGB2 (CD18) | A8MYE6 | Integrin beta | 2.9 | 3.66 | 0.00068 | 1047.7857 | 0.11764 | 520 R.TTEGCLNPR.R 530 |
| ODZ3 | Q9P273 | Teneurin-3 | 2.5 | 4.03 | 0.00004 | 2254.3396 | 0.17867 | 897 R.QDGMFDLVANGGASLTLVFER.S 920 |
| CORO2A | Q92828 | Coronin-2A | 2.4 | 2.21 | 0.00128 | 1550.6224 | 0.22761 | 235 K.KLMSTGTSRWNNR.Q 249 |
| C19orf2 | Q8TC23 | C19orf2 protein | 2.3 | 2.91 | 0.01076 | 1088.1358 | 0.47804 | 344 R.INTGKNTTLK.F 355 |
| DMD | P11532 | Isoform 4 of Dystrophin | 2.1 | 4.05 | 0.00033 | 1226.9591 | 0.20370 | 602 K.LAVLKADLEKK.K 614 |
| SYCP2 | Q9BX26 | Synaptonemal complex protein 2 | 2.1 | 3.18 | 0.00454 | 1427.8801 | 0.06260 | 509 R.IKPPLQMTSSAEK.P 523 |
| DKFZp686D0972 | Q562R1 | hypothetical protein LOC345651 | 1.9 | 2.27 | 0.00140 | 1791.0197 | 0.11971 | 239 R.SYELPDGQVITIGNER.F 256 |
| CDNA FLJ41329 fis, clone BRAMY2047676 | Q6ZWC4 | none | 1.9 | 3.05 | 0.00548 | 1546.8087 | 0.08170 | 107 R.ALNLGAATVLRRHR.A 122 |
| SLC22A11 | Q9NSA0 | Isoform 1 of Solute carrier family 22 member 11 | 1.9 | 2.63 | 0.00783 | 2210.0904 | 0.46292 | 301 R.INGHKEAKNLTIEVLMSSVK.E 322 |
| RPS27A | P62979 | UBC;UBB ubiquitin and ribosomal protein S27a precursor | 1.8 | 3.39 | 0.01933 | 1788.1465 | 0.15637 | 11 K.TITLEVEPSDTIENVK.A 28 |
| ARL6IP5 | O75915 | PRA1 family protein 3 | 1.8 | 2.85 | 0.00053 | 1312.8985 | 0.35814 | 9 R.AWDDFFPGSDR.F 21 |
| ACTB | P60709 | Actin, cytoplasmic 1 | 1.8 | 4.57 | 0.00029 | 1132.7391 | 0.08870 | 196 R.GYSFTTTAER.E 207 |
| GPR179 | A8MWI1 | Probable G-protein coupled receptor 179 precursor | 1.7 | 4.26 | 0.00002 | 1150.9204 | 0.12430 | 2099 R.GSSEAAGSVETR.V 2112 |
| HSPA9 | P38646 | heat shock 70kDa protein 9, mitochondrial precursor | 1.7 | 4.66 | 0.04236 | 1450.7788 | 0.13564 | 85 R.TTPSVVAFTADGER.L 100 |
| FAM62A | Q9BSJ8 | Isoform 1 of Protein FAM62A | 1.6 | 2.68 | 0.02300 | 1402.3521 | 0.45065 | 106 R.QLLDDEEQLTAK.T 119 |
| ELMO2 | Q7Z5G9 | ELMO2 protein | 1.6 | 3.18 | 0.01234 | 1484.9090 | 0.09548 | 1 MERTQSSNMETR.L 13 |
| CCDC73 | Q6ZRK6 | Isoform 1 of Coiled-coil domain-containing protein 73 | 1.6 | 2.39 | 0.01896 | 1583.8480 | 0.08212 | 84 K.EAMAVFKKQLQMK.M 98 |
| Down-regulated in VKH | ||||||||
| PRPH | P41219 | Isoform 1 of Peripherin | 0.60 | 2.88 | 0.01008 | 1309.9330 | 0.17343 | 398 K.LLEGEESR.I 407 |
| ATP5A1 | P25705 | ATP synthase subunit alpha, mitochondrial precursor | 0.60 | 2.54 | 0.00232 | 1316.9060 | 0.22248 | 218 K.TSIAIDTIINQK.R 231 |
| CANX | B4DGP8 | Calnexin precursor | 0.37 | 2.70 | 0.00003 | 1488.7949 | 0.25015 | 480 R.IVDDWANDGWGLK.K 494 |
| AKNA | Q7Z591 | Isoform 1 of AT-hook-containing transcription factor | 0.33 | 3.75 | 0.00007 | 1236.9160 | 0.16416 | 330 R.PLPRQGATLAGR.S 342 |
| ITGB2(CD18) | P05107 | Integrin beta-2 precursor | 0.24 | 2.54 | 0.00017 | 1090.0657 | 0.37385 | 155 R.ALNEITESGR.I 166 |
a: average expression ratio;
b: cross-correlation score.