Figure 7. EZH2 inhibitor DZNep reduced glioblastoma-induced angiogenesis in vivo.

(A) A total of 1×10⁶ U87-Fluc-mCherry cells were implanted s.c. and imaged with a CCD camera 3 days later. At days 3, 5 and 7 after implantation followed by weekly injection, one set of mice was injected i.v. with DZNep and another set with PBS. Tumor growth was monitored by in vivo bioluminescence imaging. (B) Lectin-FITC was injected i.v. prior to sacrificing the mice and was used to determine the tumor blood vessels. (C) Quantification of (B). (n = 5) Error bars indicate s.d. *p<0.05, ***p<0.001, t test.