Table 1. Inhibition of NS5B RNA Dependent RNA Polymerase (RdRp) Activity by SIL and silibinin (SbN).
RdRp | Drug | Max inhibition (%) | IC50 (µM) |
BK | SIL | 58.8 | 39.9 |
SbN | 67.3 | 210.0 | |
234 | SIL | 43.1 | 43.9 |
SbN | 57.0 | 169.0 | |
242 | SIL | 57.3 | 64.3 |
SbN | 45.7 | ∼1000 | |
245 | SIL | 49.5 | 84.9 |
SbN | 58.8 | 359.0 | |
103 | SIL | 72.8 | 40.2 |
SbN | 69.3 | 354.0 |
Polymerase assays were conducted as described in the Materials and Methods.