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. 2011 Jan 28;6(1):e16464. doi: 10.1371/journal.pone.0016464

Table 1. Inhibition of NS5B RNA Dependent RNA Polymerase (RdRp) Activity by SIL and silibinin (SbN).

RdRp Drug Max inhibition (%) IC50 (µM)
BK SIL 58.8 39.9
SbN 67.3 210.0
234 SIL 43.1 43.9
SbN 57.0 169.0
242 SIL 57.3 64.3
SbN 45.7 ∼1000
245 SIL 49.5 84.9
SbN 58.8 359.0
103 SIL 72.8 40.2
SbN 69.3 354.0

Polymerase assays were conducted as described in the Materials and Methods.