Figure 5. Attenuation of fMRI response by OX1R or OX2R antagonism.
Regions of reduced amphetamine-induced rCBV response following pre-treatment with GSK1059865 (OX1Rant; top) or JNJ10397049 (OX2Rant, bottom). Blue indicates reduced rCBV response versus control (vehicle-amphetamine). Cpu: caudate putamen; SS ctx: somatosensory cortex; Ins: insular cortex, AcS: shell of the nucleus accumbens.