Skip to main content
. 2011 Jan 28;6(1):e16564. doi: 10.1371/journal.pone.0016564

Figure 3. The effect of CEppt on cognitive performances and Aβ oligomer formation in 5XFAD Alzheimer's disease model mice.

Figure 3

(A) Object recognition test of transgenic AD model mice (5XFAD), non-transgenic littermate (W.T.), and 5XFAD treated mice. Placebo 5XFAD mice were given drinking water (n = 8); W.T mice were given drinking water (n = 8); treated 5XFAD mice were given water with CEppt (100 µg/ml) (n = 7). One-way ANOVA tests show Pv = 0.0413. (B) Soluble fraction of mouse brain homogenates were analyzed by western blot probed with Aβ antibody 6E10. (C) Western blot band signals for 56 kDa in (B) were quantified using densitometry and displayed as Percent of 56 kDa toxic oligomer band intensity. (D) Insoluble fraction of mouse brain homogenates were analyzed by western blot probed with Aβ antibody 6E10, quantified using densitometry, and displayed as relative intensities of total Aβ signals.