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. 2011 Jan 28;6(1):e16604. doi: 10.1371/journal.pone.0016604

Table 2. Associations between LPA SNPs and Lp(a) levels.

SNPs Non-Hispanic Whitesn = 2,397 Non-Hispanic Blacksn = 1,711 Mexican Americansn = 1,749
β(95% CI) R2 P-value β(95% CI) R2 P-value β(95% CI) R2 P-value
rs1321196 −0.13(−0.22, −0.05) 0.0036 0.0026 0.21(0.14, 0.28) 0.0193 1.88×10−8 0.12(0.02, 0.22) 0.0031 0.0204
rs1321195 0.05(−0.07, 0.18) 0.0003 0.3863 0.53(0.31, 0.75) 0.0123 3.03×10−6 0.40(0.23, 0.56) 0.0127 3.49×10−6
rs1367211 −0.004(−0.10, 0.09) 0.0000 0.9330 −0.27(−0.34, −0.20) 0.0345 3.67×10−14 −0.15(−0.26, 0.04) 0.0039 0.0092
rs1652507 −0.05(−0.16, 0.05) 0.0005 0.3295 −0.45(−0.59, −0.32) 0.0247 1.06×10−10 −0.54(−0.63, −0.46) 0.0858 5.44×10−34
rs6907156 0.21(−0.51, 0.92) 0.0001 0.5722 0.15(0.05, 0.25) 0.0053 0.0031 0.73(0.39, 1.06) 0.0103 2.14×10−5
rs6919346 0.61(0.51, 0.71) 0.0565 1.18×10−30 0.75(0.56, 0.94) 0.0344 2.16×10−14 0.18(0.02, 0.33) 0.0029 0.0248
rs6926458 −0.23(−0.32, −0.13) 0.0087 5.29×10−6 −0.45(−0.57, −0.34) 0.0364 5.90×10−15 −0.15(−0.28, 0.03) 0.0032 0.0189
rs7755463 −0.47(−0.99, 0.06) 0.0014 0.0823 −0.33(−0.40, −0.25) 0.0449 4.01×10−18 −0.89(−1.16. −0.62) 0.0230 2.14×10−10
rs7767084 0.07(−0.05, 0.18) 0.0006 0.2467 −0.41(−0.61, −0.21) 0.0097 5.88×10−5 0.10(−0.03, 0.23) 0.0015 0.1187
rs9364564 0.19(0.08, 0.29) 0.0049 0.0007 0.33(0.21, 0.46) 0.0156 2.29×10−7 0.11(−0.02, 0.24) 0.0016 0.1053
rs12212507 0.03(−0.15, 0.21) 0.0001 0.7633 0.63(0.23, 1.03) 0.0063 0.0019 0.57(0.14, 1.00) 0.0037 0.0093
rs13192132 −0.14(−0.23, −0.06) 0.0043 0.0011 −0.43(−0.53, −0.33) 0.0425 3.85×10−17 −0.003(−0.11, 0.10) 0.0000 0.9508
rs10945682 0.12(0.04, 0.21) 0.0033 0.0041 −0.14(−0.21, −0.06) 0.0079 0.0003 −0.16(−0.26, −0.06) 0.0055 0.0022
rs12194138 −0.41(−0.52, −0.30) 0.0229 2.05×10−13 0.34(0.12, 0.56) 0.0020 0.0014 −0.47(−0.66, −0.28) 0.0149 7.97×10−7
rs7450261 0.10(−1.29, 1.48) 0.0000 0.8907 0.35(0.18, 0.51) 0.0108 2.84×10−5 −0.33(−1.34, 0.68) 0.0003 0.5176
rs7450411 0.19(0.08, 0.30) 0.0051 0.0005 0.37(0.27, 0.47) 0.0308 7.37×10−13 0.12(−0.02, 0.25) 0.0017 0.0910
rs7765803 −0.05(−0.14, 0.04) 0.0005 0.2471 0.13(0.06, 0.20) 0.0071 0.0005 0.21(0.10, 0.31) 0.0089 8.54×10−5
rs41265936 −0.80(−2.04, 0.44) 0.0007 0.2037 −0.22(−0.37, −0.06) 0.0047 0.0054 −0.88(−1.48, −0.28) 0.0046 0.0039
rs41271028 −0.45(−1.22, 0.32) 0.0006 0.2556 −0.06(−0.18, 0.07) 0.0007 0.3608 −0.66(−1.06, −0.27) 0.0061 0.0011

The association of LPA SNPs with log transformed Lp(a) levels is shown by a regression coefficient (beta, β) and 95% confidence interval (CI) for each SNP, adjusted for age and sex. Measures of variance explained (R2) are provided for each SNP based on unadjusted regressions. Significant associations (P-value<0.0001) are in bold.