Table 4.
Traits Related to Kidney Disease, Diabetes, and CVD in GKDZI Study Participants, by Sex
| Trait | All Participants | No. (women/men) | Women | Men | Pa |
|---|---|---|---|---|---|
| eGFRMDRD-AI (mL/min/1.73m2) | 116.14 ± 28.7 | 396/411 | 113.53 ± 31.2 | 118.65 ± 25.9 | 0.002 |
| UACR | 129.28 ± 566.1 | 397/413 | 100.68 ± 417.5 | 156.77 ± 678.3 | 0.3 |
| SCr (mg/dL) | 0.916 ± 0.88 | 404/416 | 0.864 ± 0.99 | 0.968 ± 0.77 | <0.001 |
| SUN (mg/dL) | 12.29 ± 6.4 | 404/415 | 12.52 ± 7.6 | 12.06 ± 5.1 | 0.7 |
| Uric acid (mg/dL) | 5.92 ± 1.7 | 403/415 | 5.17 ± 1.4 | 6.64 ± 1.6 | <0.001 |
| Hematuriab | 2.18 ± 10.6 | 397/412 | 3.04 ± 14.6 | 1.34 ± 3.3 | <0.001 |
| Weight (lb) | 166.99 ± 40.6 | 405/416 | 161.81 ± 38.8 | 172.04 ± 41.8 | <0.001 |
| BMI (kg/m2) | 29.44 ± 6.8 | 405/416 | 30.99 ± 7.4 | 27.93 ± 5.9 | <0.001 |
| HbA1c (%) | 5.81 ± 1.4 | 405/416 | 5.91 ± 1.4 | 5.72 ± 1.3 | 0.02 |
| SBP (mm Hg) | 122.54 ± 16.6 | 405/416 | 117.78 ± 15.0 | 127.17 ± 16.8 | <0.001 |
| DBP (mm Hg) | 77.70 ± 11.5 | 405/416 | 75.07 ± 10.0 | 80.27 ± 12.3 | <0.001 |
| HDL-C (mg/dL) | 49.47 ± 16.1 | 385/387 | 48.30 ± 14.5 | 50.64 ± 17.4 | 0.07 |
| LDL-C (mg/dL) | 98.29 ± 31.2 | 350/361 | 94.54 ± 27.5 | 101.93 ± 34.0 | 0.01 |
| Triglycerides (mg/dL) | 171.50 ± 131.4 | 402/414 | 169.35 ± 108.8 | 173.59 ± 150.3 | 0.5 |
| Total cholesterol (mg/dL) | 180.15 ± 38.3 | 402/414 | 175.16 ± 35.2 | 184.99 ± 40.5 | <0.001 |
Note: Unless otherwise indicated, values shown are mean ± standard error.
Abbreviations and definitions: BMI, body mass index; CVD, cardiovascular disease; DBP, diastolic blood pressure; eGFR, estimated glomerular filtration rate; eGFRMDRD-AI, estimated glomerular filtration rate calculated using the Modification of Diet in Renal Disease Study equation modified for American Indians; GKDZI, Genetics of Kidney Disease in Zuni Indians; HbA1c, glycated hemoglobin; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; SBP, systolic blood pressure; SCr, serum creatinine; SUN, serum urea nitrogen; UACR, urinary albumin-creatinine ratio.
All traits were inverse normalized to test differences between the 2 groups.
Hematuria is defined as 3 or more red blood cells per high-power field.