Table 6.
Traits Related to Kidney Disease, Diabetes, and CVD in GKDZI Study Participants, by HTN Status
| Trait | No. (no HTN/HTN) | Participants Without HTN | Participants With HTN | Pa |
|---|---|---|---|---|
| eGFRMDRD-AI (mL/min/1.73 m2) | 533/274 | 119.15 ± 26.6 | 110.27 ± 31.6 | <0.001 |
| UACR | 533/277 | 36.75 ± 148.4 | 307.32 ± 921.1 | <0.001 |
| SCr (mg/dL) | 534/286 | 0.799 ± 0.18 | 1.13 ± 1.5 | <0.001 |
| SUN (mg/dL) | 533/286 | 11.26 ± 3.5 | 14.20 ± 9.5 | <0.001 |
| Uric acid (mg/dL) | 532/286 | 5.74 ± 1.6 | 6.24 ± 1.7 | <0.001 |
| Hematuriab | 532/277 | 2.45 ± 12.7 | 1.66 ± 4.2 | 0.05 |
| Weight (lb) | 535/286 | 159.73 ± 35.9 | 180.57 ± 45.2 | <0.001 |
| BMI (kg/m2) | 535/286 | 28.35 ± 6.4 | 31.48 ± 7.0 | <0.001 |
| HbA1c (%) | 535/286 | 5.48 ± 0.88 | 6.43 ± 1.9 | <0.001 |
| SBP (mm Hg) | 535/286 | 115.34 ± 11.2 | 136.00 ± 16.8 | <0.001 |
| DBP (mm Hg) | 535/286 | 73.65 ± 8.3 | 85.29 ± 12.8 | <0.001 |
| HDL-C (mg/dL) | 501/271 | 49.46 ± 15.6 | 49.49 ± 16.9 | 0.6 |
| LDL-C (mg/dL) | 464/247 | 96.37 ± 28.3 | 101.90 ± 35.7 | 0.1 |
| Triglycerides (mg/dL) | 530/286 | 152.92 ± 105.0 | 205.94 ± 164.6 | <0.001 |
| Total cholesterol (mg/dL) | 530/286 | 175.7 ± 35.4 | 188.39 ± 41.9 | <0.001 |
Note: Unless otherwise indicated, values shown are mean ± standard error.
Abbreviations and definitions: BMI, body mass index; CVD, cardiovascular disease; DBP, diastolic blood pressure; eGFR, estimated glomerular filtration rate; eGFRMDRD-AI, estimated glomerular filtration rate calculated using the Modification of Diet and Renal Disease Study equation modified for American Indians; GKDZI, Genetics of Kidney Disease in Zuni Indians; HbA1c, glycated hemoglobin (based on American Diabetes Association criteria); HDL-C, high-density lipoprotein cholesterol; HTN, hypertension; LDL-C, low-density lipoprotein cholesterol; SBP, systolic blood pressure; SCr, serum creatinine; SUN, serum urea nitrogen; UACR, urinary albumin-creatinine ratio.
All traits were inverse normalized to test differences between the 2 groups.
Hematuria is defined as 3 or more red blood cells per high-power field.