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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Am J Kidney Dis. 2010 Jun 19;56(2):289–302. doi: 10.1053/j.ajkd.2010.03.012

Table 9.

Genetic and Environmental Correlations Between Intermediate Phenotypes Related to Kidney Disease and Traits Related to Obesity, Diabetes, and CVD

Trait 1 Trait 2 ρg ± SE P ρe ± SE P
eGFRMDRD-AI BMI 0.155 ± 0.16 0.3 −0.099 ± 0.09 0.3
Weight 0.086 ± 0.15 0.6 −0.084 ± 0.09 0.4
HbA1c −0.194 ± 0.19 0.3 0.089 ± 0.07 0.2
SBP 0.166 ± 0.17 0.3 −0.101 ± 0.07 0.2
DBP 0.161 ± 0.19 0.4 −0.012 ± 0.07 0.9
HTN status (yes/no) 0.305 ± 0.19 0.1 −0.135 ± 0.07 0.07
HDL-C 0.094 ± 0.16 0.6 0.227 ± 0.07 0.004
Total cholesterol −0.029 ± 0.17 0.9 0.076 ± 0.08 0.3
Triglycerides 0.036 ± 0.19 0.9 −0.182 ± 0.07 0.01
UACR BMI 0.212 ± 0.16 0.2 0.004 ± 0.09 0.9
Weight 0.110 ± 0.15 0.5 0.045 ± 0.09 0.6
HbA1c 0.204 ± 0.20 0.3 0.173 ± 0.07 0.02
SBP 0.421 ± 0.15 0.02 0.177 ± 0.07 0.02
DBP 0.478 ± 0.18 0.02 0.107 ± 0.07 0.1
HTN status (yes/no) 0.563 ± 0.16 0.003 0.264 ± 0.06 <0.001
HDL-C 0.063 ± 0.17 0.7 0.082 ± 0.08 0.3
Total cholesterol 0.185 ± 0.17 0.3 0.095 ± 0.08 0.2
Triglycerides 0.070 ± 0.20 0.7 0.111 ± 0.07 0.1
SCr BMI −0.187 ± 0.18 0.3 0.077 ± 0.08 0.3
Weight −0.182 ± 0.18 0.3 0.093 ± 0.09 0.3
HbA1c 0.231 ± 0.20 0.3 −0.083 ± 0.07 0.2
SBP −0.103 ± 0.19 0.6 0.013 ± 0.07 0.8
DBP −0.193 ± 0.20 0.4 −0.020 ± 0.06 0.8
HTN status (yes/no) −0.261 ± 0.21 0.2 0.076 ± 0.07 0.3
HDL-C −0.011 ± 0.18 0.9 −0.220 ± 0.07 0.003
Total cholesterol 0.080 ± 0.19 0.7 −0.085 ± 0.07 0.2
Triglycerides −0.011 ± 0.21 0.9 0.148 ± 0.07 0.03
SUN BMI 0.044 ± 0.18 0.8 0.008 ± 0.09 0.9
Weight 0.135 ± 0.17 0.4 −0.027 ± 0.09 0.8
HbA1c 0.664 ± 0.23 0.005 −0.022 ± 0.07 0.7
SBP −0.379 ± 0.20 0.06 −0.048 ± 0.07 0.5
DBP −0.273 ± 0.21 0.2 −0.072 ± 0.07 0.3
HTN status (yes/no) −0.372 ± 0.21 0.08 0.171 ± 0.08 0.02
HDL-C −0.227 ± 0.18 0.2 −0.289 ± 0.07 <0.001
Total cholesterol 0.059 ± 0.19 0.8 −0.159 ± 0.07 0.03
Triglycerides −0.169 ± 0.23 0.5 0.145 ± 0.07 0.04
Uric acid BMI 0.296 ± 0.14 0.06 0.198 ± 0.08 0.02
Weight 0.267 ± 0.14 0.07 0.186 ± 0.09 0.05
HbA1c 0.223 ± 0.19 0.3 −0.052 ± 0.07 0.5
SBP 0.290 ± 0.17 0.1 0.123 ± 0.07 0.09
DBP 0.124 ± 0.19 0.5 0.220 ± 0.07 0.001
HTN status (yes/no) 0.188 ± 0.19 0.3 0.092 ± 0.07 0.2
HDL-C −0.303 ± 0.15 0.06 −0.094 ± 0.08 0.2
Total cholesterol 0.134 ± 0.17 0.4 0.138 ± 0.07 0.7
Triglycerides 0.325 ± 0.17 0.09 0.190 ± 0.07 0.009

Note: Glucose excluded because many participants were not fasting. No significant genetic or environmental correlation with LDL-C.

Abbreviations and definitions: BMI, body mass index; CVD, cardiovascular disease; DBP, diastolic blood pressure; eGFR, estimated glomerular filtration rate; eGFRMDRD-AI, estimated glomerular filtration rate calculated by the Modification of Diet and Renal Disease Study equation modified for American Indians; HbA1c, glycated hemoglobin; HDL-C, high-density lipoprotein cholesterol; HTN, hypertension; ρg, genetic correlation coefficient; ρe, environmental correlation coefficient; SBP, systolic blood pressure; SCr, serum creatinine; SE, standard error of variance; SUN, serum urea nitrogen; UACR, urinary albumin-creatinine ratio.