Table 2. Comparison of ORs for Risk Alleles in the European (7) and African-American Populations.
A. Odds Ratios for 24 risk alleles (SNPs) for which ORs were consistent (overlapping confidence intervals) between African-American and European populations. B. Odds Ratios for 3 risk alleles (SNPs) for which ORs were inconsistent between African-American and European populations.
| SNP | Chr | Gene | Min/Maj Allele* |
MAF (cases) |
MAF (controls) |
P value | African-American OR |
European OR | MAF European Cases |
Statistical Power |
|---|---|---|---|---|---|---|---|---|---|---|
| rs3087243 | 2 | CTLA4 | A/G | 0.19 | 0.24 | 0.003 | 0.75 (0.62–0.91) | 0.87 (0.83–0.91) | 0.44 | 0.340 |
| rs11889341** | 2 | STAT4 | T/C | 0.15 | 0.13 | 0.071 | 1.22 (0.98–1.53) | 1.16 (1.10–1.23) | 0.22 | 0.231 |
| rs1980422 | 2 | CD28 | C/T | 0.22 | 0.19 | 0.073 | 1.19 (0.98–1.44) | 1.12 (1.06–1.18) | 0.24 | 0.216 |
| rs3761847 | 9 | TRAF1-C5 | A/G | 0.41 | 0.38 | 0.128 | 1.13 (0.97–1.32) | 1.13 (1.08–1.18) | 0.43 | 0.326 |
| rs6859219 | 5 | ANKRD55 | T/C | 0.03 | 0.04 | 0.144 | 0.73 (0.48–1.12) | 0.85 (0.78–0.93) | 0.18 | 0.139 |
| rs10499194† | 6 | TNFAIP3 | T/C | 0.18 | 0.16 | 0.164 | 1.16 (0.94–1.42) | 0.91 (0.87–0.96) | 0.27 | 0.148 |
| rs13031237 | 2 | REL | T/G | 0.10 | 0.08 | 0.185 | 1.20 (0.92–1.56) | 1.13 (1.07–1.18) | 0.37 | 0.146 |
| rs934734 | 2 | SPRED2 | G/A | 0.46 | 0.49 | 0.231 | 1.10 (0.94–1.28) | 1.13 (1.06–1.21) | 0.52 | 0.346 |
| rs2812378 | 9 | CCL21 | G/A | 0.45 | 0.42 | 0.232 | 1.10 (0.94–1.28) | 1.10 (1.05–1.16) | 0.34 | 0.228 |
| rs3890745 | 1 | TNFRSF14 | C/T*** | 0.52 | 0.54 | 0.270 | 0.92 (0.79–1.07) | 0.89 (0.85–0.94) | 0.32 | 0.318 |
| rs11586238† | 1 | CD58 | G/C | 0.09 | 0.10 | 0.281 | 0.87 (0.67–1.13) | 1.13 (1.07–1.19) | 0.24 | 0.164 |
| rs10919563† | 1 | PTPRC | A/G | 0.40 | 0.38 | 0.342 | 1.08 (0.92–1.26) | 0.88 (0.82–0.94) | 0.13 | 0.362 |
| rs548234 | 6 | PRDM1 | C/T | 0.08 | 0.07 | 0.436 | 1.12 (0.84–1.49) | 1.10 (1.05–1.16) | 0.33 | 0.100 |
| rs2476601 | 1 | PTPN22 | A/G | 0.02 | 0.01 | 0.507 | 1.23 (0.66–2.29) | 1.94 (1.81–2.08) | 0.10 | 0.665 |
| rs10488631 | 7 | IRF5 | T/C | 0.03 | 0.03 | 0.530 | 1.16 (0.72–1.87) | 1.25 (1.14–1.37) | 0.13 | 0.156 |
| rs3218253 | 22 | IL2RB | A/G | 0.15 | 0.13 | 0.575 | 1.07 (0.85–1.33) | 1.09 (1.03–1.15) | 0.26 | 0.121 |
| rs706778 | 10 | IL2RA | C/T | 0.50 | 0.49 | 0.656 | 1.04 (0.89–1.21) | 1.11 (1.06–1.17) | 0.44 | 0.268 |
| rs26232 | 5 | C5orf13, | T/C | 0.29 | 0.30 | 0.687 | 0.97 (0.82–1.14) | 0.93 (0.88–0.98) | 0.29 | 0.138 |
| rs540386 | 11 | TRAF6 | T/C | 0.25 | 0.25 | 0.756 | 0.97 (0.81–1.16) | 0.88 (0.83–0.94) | 0.14 | 0.307 |
| rs874040 | 4 | RBPJ | C/G | 0.34 | 0.34 | 0.771 | 1.02 (0.87–1.21) | 1.18 (1.12–1.24) | 0.33 | 0.530 |
| rs13315591† | 3 | PXK | C/T | 0.34 | 0.35 | 0.799 | 0.98 (0.83–1.15) | 1.13 (1.04–1.23) | 0.10 | 0.326 |
| rs4750316† | 10 | PRKCQ | C/G | 0.39 | 0.38 | 0.813 | 1.02 (0.87–1.19) | 0.87 (0.82–0.92) | 0.19 | 0.417 |
| rs6822844† | 4 | IL2, IL21 | T/G | 0.02 | 0.02 | 0.829 | 1.06 (0.63–1.77) | 0.90 (0.84–0.95) | 0.18 | 0.069 |
| rs4810485† | 20 | CD40 | T/G | 0.07 | 0.07 | 0.908 | 1.02 (0.75–1.38) | 0.85 (0.80–0.90) | 0.25 | 0.196 |
| A | ||||||||||
| SNP | Chr | Gene |
Min/Maj Allele |
MAF (cases) |
MAF (controls) |
P value |
African- American OR |
European OR |
MAF European Cases |
Statistical Power |
| rs3093023 | 6 | CCR6 | A/G | 0.14 | 0.17 | 0.035 | 0.79 (0.64–0.98) | 1.11 (1.06–1.16) | 0.47 | 0.175 |
| rs394581 | 6 | TAGAP | C/T | 0.47 | 0.43 | 0.080 | 1.15 (0.98–1.34) | 0.91 (0.87–0.96) | 0.30 | 0.225 |
| rs6920220 | 6 | TNFAIP3 | A/G | 0.10 | 0.11 | 0.321 | 0.88 (0.68–1.13) | 1.22 (1.16–1.29) | 0.22 | 0.383 |
| B | ||||||||||
Note that four SNPs had OR in opposite directions.
Minor and major allele frequencies refer to the African-American population.
Genotyping results have previously been reported on this SNP which is a proxy SNP for rs7574865 (see Discussion).
Minor allele for SNP rs3890745 (TNFRSF14) was switched for computing the African American OR to reflect the minor allele found in the European population.
Demonstrate OR in the opposite direction compared to European RA but the CIs overlap between the two populations indicating no statistically significant difference.
Note that all three OR were in opposite directions and the confidence limits did not overlap.