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. Author manuscript; available in PMC: 2012 Feb 11.
Published in final edited form as: J Mol Biol. 2010 Nov 25;406(1):75–91. doi: 10.1016/j.jmb.2010.11.031

Fig. 3.

Fig. 3

Structures of apo-caspase-6 ΔN D179A and ΔN D179 CT. (a) Superposition of caspase-6 ΔN D179A (orange) and ΔN D179 CT (tan) and an independently determined caspase-6 structure (2WDP, blue). The boxed region indicates the substrate binding groove region that is shown in (b). (b) Superposition of unliganded mature caspase-6 ΔN D179A (orange) with liganded mature caspase-7 (1F1J, green) allosterically inhibited caspase-7 (1SHJ, pink), caspase-7 zymogen (1GQF, blue), and unliganded caspase-7 (1K86, gray) focusing on the substrate-binding loop region including loops L2, L3 and L4 from chain A of the dimer and L2’ from chain B of the dimer. Disordered regions not observed in the crystal structure account for the discontinuity in the middle of loops L3 and L4 in some of the structures.