Table 4.

Univariate analysis of factors predicting toxicity index (TI).

Parameter	Parameter coefficient††	Standard Error	Lower 95% CI*	Upper 95% CI	P value
ARM A†	−0.506	0.200	−0.897	−0.114	0.011
SAE	0.663	0.220	0.232	1.095	0.003
Dd-C1D1	0.116	0.031	0.054	0.177	<0.0001
Dd-C3D1	0.464	0.133	0.203	0.724	<0.0001
Dd-C3D15	0.242	0.102	0.041	0.442	0.018
TAT-C3D15	0.282	0.060	0.164	0.400	<0.0001
CEC-C2D1	0.002	0.001	0.000	0.004	0.025
VEGF-C2D1	−0.005	0.002	−0.009	0.000	0.033
VEGF-C2D15	−0.005	0.002	−0.009	0.000	0.030

^†Patients on Arm A (bevacizumab only) had lower TI.

^††Parameter coefficient describes amount of change in the TI if a parameter changes by one unit.

^*CI, confidence interval.

SAE, severe adverse event; Dd, D-dimer; TAT, thrombin/antithrombin complex; CEC, circulating endothelial cells; VEGF, vascular endothelial growth factor