. Author manuscript; available in PMC: 2012 Mar 1.

Published in final edited form as: Behav Pharmacol. 2010 Dec;21(8):736–744. doi: 10.1097/FBP.0b013e32833fa79d

Table 1.

Outline of experimental design detailing tests conducted before, during and after chronic pregnanolone treatment.

	Treatment dose (mg/kg/day)	Week of treatment	Test
Before	0	--	Pregnanolone time course
Before	0	--	Dose-effect curves for all drugs
During	5.6	1, 2	Pregnanolone and flunitrazepam dose-effect curves^a
	11.2	3-6	Pregnanolone and flunitrazepam dose-effect curves^a
	11.2	7	Ketamine dose-effect curves
	16.8	8, 9	Pregnanolone and flunitrazepam dose-effect curves^a
	25.6	10, 11	Pregnanolone and flunitrazepam dose-effect curves^a
	25.6	12-20	Dose-effect curves for all drugs
After	0	2 weeks after	Pregnanolone and flunitrazepam dose-effect curves^a
After	0	4 weeks after	Dose-effect curves for all drugs

Pregnanolone dose-effect curves were determined on the fourth day of each week and flunitrazepam dose-effect curves were determined on the seventh day of each week.