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. 2010 Jan 3;1(2):179–189. doi: 10.4161/nucl.1.2.11113

Figure 2.

Figure 2

Significant dose dependent effect of LBR on the number of nuclear segments in neutrophils, calculated by the “Drittelregel”. (A) The differences between 0, 1, 2 and 3 functional LBR copies are highly significant (p < 0.0001) in terms of mean values and standard deviation (0 LBR-genes: 1.130 ± 0.338; 1 LBR-gene: 1.596 ± 0.522; 2 LBR-genes: 2.573 ± 0.856; 3 LBR-genes: 3.213 ± 1.072). The graph is based on the analysis of 1,300 neutrophil nuclei derived from 26 individuals (2 patients with no wild type allele, 9 individuals with one wild type allele, 12 controls with two wild type alleles and 3 patients with three wild type alleles). 50 neutrophils were analyzed per individual.