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Significant dose dependent effect of LBR on the number of nuclear segments in neutrophils, calculated by the “Drittelregel”. (B) The mutation type (null or splicing defect) significantly influences nuclear segmentation in neutrophils of heterozygous Pelger individuals. We analyzed four individuals heterozygous for null mutations (p.V11E fs X14, p.R89X and two individuals with mutation p.R377X, respectively) and five individuals heterozygous for splice mutation IVS12-5-10del.
