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Effects of 0 to 3 functional (wild type) copies of the LBR-gene on nuclear segmentation and LBR protein level. The number of functional LBR copies correlates with the nuclear segmentation of neutrophils in blood smears, the staining intensity of the nuclear membrane in lymphoblastoid cells in immunofluorescence microscopy with an anti-LBR antibody, and the amount of LBR protein in western blots from lymphoblastoid cells.
