Table 2.

Time to onset of common adverse effects

Symptoms	Typical time of onset
Constitutional symptoms
Fever, myalgias, headache, arthralgias, nausea	Minutes to day
Neuropsychiatric symptoms
Depression	12 weeks to 6 months
Dermatological symptoms
Rash	Minutes (localized, injection site) to weeks
Hematological symptoms
Neutropenia	2–6 weeks
Anemia	1 day to 4 weeks
Thrombocytopenia	1–14 days