Figure 5.

The estimated annual CDR-SB increase and 95% confidence intervals by predictor stratified by anatomical subtype. We define ‘low’ to be the 15th percentile (P15) and ‘high’ to be the 85th percentile (P85). The executive, language and visuospatial composite scores are adjusted for age at baseline and education and worse performance corresponds to a lower score and greater annual increase as can be seen in the temporofrontoparietal (TFP) and frontal dominant (FD) subtype; a less dramatic trend was observed for the temporal dominant subtype (TD). FT = frontotemporal subtype; NPI = Neuropsychiatric Inventory.