Table 4.
Multivariable Linear Regression Models of Physical Function in HIV-Infected and Uninfected Subjects
| |
HIV uninfected N = 3126 |
HIV infected N = 3081 |
Difference (HIV infected-uninfected) |
||||||
|---|---|---|---|---|---|---|---|---|---|
| b | 95% CI | p Value | b | 95% CI | p Value | Delta | SE | p Valuea | |
| Age, per year | −0.08 | (−0.16, −0.01) | 0.03 | −0.2 | (−0.33, −0.17) | < .0001 | −0.17 | 0.06 | < 0.01 |
| Gender, female | −1.4 | (−3.87,1.14) | 0.29 | −4.7 | (−8.97, −0.35) | 0.03 | −3.30 | 2.54 | 0.19 |
| Race | |||||||||
| Black | 1.4 | (−0.19,3.01) | 0.09 | 0.8 | (−1.01,2.54) | 0.40 | −0.64 | 1.22 | 0.60 |
| Hispanic | −0.2 | (−2.67,2.27) | 0.87 | −2.7 | (−5.34,0.03) | 0.05 | −2.45 | 1.86 | 0.19 |
| Lifestyle factors: | |||||||||
| Body mass index (BMI, kg/m2) | |||||||||
| Underweight (BMI < 18.5) | −1.8 | (−7.89,4.26) | 0.56 | −6.2 | (−9.99, −2.41) | < 0.01 | −4.39 | 3.65 | 0.23 |
| Overweight (BMI 25.0–29.9) | 0.5 | (−1.26,2.24) | 0.58 | 1.3 | (−0.21,2.78) | 0.09 | 0.79 | 1.17 | 0.50 |
| Obese (BMI ≥ 30) | −2.6 | (−4.39, −0.73) | 0.01 | −0.9 | (−3.12,1.38) | 0.45 | 1.69 | 1.48 | 0.25 |
| Current smoker | −4.0 | (−5.4, −2.51) | < 0.0001 | −2.4 | (−3.8, −0.96) | < 0.01 | 1.58 | 1.03 | 0.13 |
| History of alcohol disorders | 0.6 | (−1.1,2.39) | 0.47 | −1.4 | (−3.28,0.48) | 0.14 | −2.04 | 1.31 | 0.12 |
| Comorbid conditions: | |||||||||
| Congestive heart failure | −6.1 | (−9.95, −2.32) | < 0.001 | −9.5 | (−14.49, −4.51) | < 0.001 | −3.37 | 3.20 | 0.29 |
| Coronary artery disease | −5.6 | (−8, −3.29) | < 0.0001 | −7.8 | (−10.99, −4.53) | < .0001 | −2.11 | 2.04 | 0.30 |
| Diabetes | −5.2 | (−6.88, −3.56) | < 0.0001 | −1.8 | (−3.88,0.38) | 0.11 | 3.47 | 1.37 | 0.01 |
| Hepatitis C | −2.2 | (−4.08, −0.26) | 0.03 | −3.8 | (−5.37, −2.25) | < 0.0001 | −1.64 | 1.26 | 0.19 |
| Hypertension | −1.6 | (−3.04, −0.1) | 0.04 | −0.02 | (−1.65,1.61) | 0.98 | 1.55 | 1.12 | 0.17 |
| Major depression | −8.2 | (−10.14, −6.32) | < 0.0001 | −4.9 | (−6.97, −2.85) | < 0.0001 | 3.32 | 1.44 | 0.02 |
| Pulmonary diseaseb | −3.8 | (−5.9, −1.69) | < 0.0001 | −7.3 | (−9.61, −4.93) | < 0.0001 | −3.48 | 1.60 | 0.03 |
| Peripheral vascular disease | −6.7 | (−10.28, −3.18) | < 0.01 | −7.2 | (−12.22, −2.13) | 0.01 | −0.44 | 3.15 | 0.89 |
| Stroke | −6.3 | (−9.85, −2.83) | < 0.001 | −6.7 | (−11.49, −1.97) | 0.01 | −0.39 | 3.02 | 0.90 |
a
p value between groups.
b
Pulmonary disease includes chronic obstructive pulmonary disease (bronchitis and emphysema) or asthma.
Reference groups: white race, normal BMI (18.6-24.9), former/never smoker, and for each comorbidity, patients without the condition based on ICD-9 codes.
CI, confidence interval.