Skip to main content
. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Synapse. 2010 Oct 8;65(5):404–411. doi: 10.1002/syn.20858

Figure 2.

Figure 2

The lack of effect of SCH23390 on plasma steady-state cocaine concentrations. Non- contingent continuous infusions of cocaine were administered to the rats via a jugular catheter. In separate sessions, the rates of cocaine infusions were 0.18, 0.36 or 0.72 μmol/kg min−1. Symbols represent the mean ± SEM plasma cocaine concentrations from 5 rats. The steady-state level of cocaine was proportional to the rate of infusion. The asterisk indicates a plasma concentration of cocaine significantly lower (*p < 0.05, one-way ANOVA with repeated measures and post-hoc Tukey’s test) than subsequent concentrations. The time of injection of SCH23390 (15 nmol/kg) is indicated by the arrow. There was no significant increase (p > 0.1, one-way ANOVA) in the mean plasma cocaine concentration 20 min after the injection of SCH23390 compared to the level of cocaine measured immediately prior to the injection of SCH23390 at any infusion rate of cocaine.