Hepatoma mTAAs (Sca-2, GP38, RABP1) |
HIV-1 SIN LV/2 VSV-G |
Twice S.C. injection of LV-transduced BMDCs in BALB/c weekly |
CTL, secreting IFN-γ |
Yes |
(163) |
Prostate cancer murine erbB2tr |
HIV-1 SIN LV /2 VSV-G |
Twice I.P. injection of LV-transduced BMDCs in C57BL/6 at 2 week interval |
erbB2tr-specific Th1 cytokine and antibody |
Yes |
(164) |
Melanoma human MAGE-A3 |
HIV-1 SIN LV /2 VSV-G |
Human MoDCs transduced by LV |
CTL (new epitope EGDCAPEEK) |
|
(49, 60, 165) |
Melanoma murine TRP2 |
HIV-1 LV/1 VSV-G |
S.C. injection of LV-transduced BMDCs in C57BL/6 |
T-cell response |
Yes |
(51, 166) |
Melanoma murine TRP2 |
HIV-1 SIN LV/3 VSV-G |
Twice I.V. injections of LV in C57BL/6, 1 week apart |
Ag-specific CD8+ T cells, secreting IFN-γ |
Yes |
(68) |
Melanoma mTRP2 Breast tumor NeuED |
HIV-1 SIN LV /2 VSV-G |
S.C. injection of LV in C57BL/6 or BALB/c-Neu |
Ag-specific CD8+ T cells, secreting IFN-γ |
Yes |
(63) |
Melanoma human Melan-A |
HIV-1 SIN LV/2 VSV-G |
Human MoDCs transduced by LV |
Antigen specific CD8+ T cells, secreting IFN-γ |
N/A |
(167) |
Melanoma hMART1, mTRP2 |
HIV-1 SIN LV/3 VSV-G |
S.C. injection of BM cells cotransduced by LV- GM-CSF/IL-4 + LV-hMART 1/mTRP2 in C57BL/6 |
Antigen specific CD8+ T cells; CTL, secreting IFN-γ |
Yes |
(61) |
Melanoma human tyrosinase |
HIV-1 SIN LV/2 VSV-G |
Human APCs transduced by LV |
Activation of Ag-specific TILs |
N/A |
(44) |
Melanoma polyepitope |
HIV-1 LV/1 VSV-G |
S.C., I.V., or I.P. injection of LV in HHD mice |
vigorous and multi-specific long term CTLs |
N/A |
(47) |
Melanoma human NY-ESO-1 |
HIV-1 SIN LV/3 VSV-G |
S.C. injection of LV in HLA-A2/H-2Kb mice |
Ag-specific T and B-cell responses |
N/A |
(162) |
Melanoma human NY-ESO-1 |
HIV-1 SIN LV/2 VSV-G |
S.C. or I.V. injection of LV in HHD mice; or boost with VV-ESO |
Ag-specific CD4+ and CD8+ T cells; CTLs |
N/A |
(64, 69) |
Melanoma human Melan-A/ELA26–35
|
HIV-1 SIN LV/3 VSV-G |
S.C. injection of LV in HLA-A2/H-2Kb mice; or boost with the same LV |
Ag-specific CD8+ T cells |
N/A |
(85, 168) |
Melanoma human Melan-A26-35
|
HIV-1 SIN LV/3 VSV-G |
S.C. injection of LV in HLA-A2/H-2Kb mice; or IL-7 as adjuvant |
Ag-specific CD8+ memory T cells; CTLs |
N/A |
(81, 93) |
Melanoma murine mutated TRP1 |
HIV-1 SIN LV/3 VSV-G |
Footpad injection of LV in C57BL/6 |
CD8+ T cells recognizing multi-epitopes; CTL cytokines; TILs |
Yes |
(155) |
Human telomerase reverse transcriptase |
HIV-1 SIN LV/2 VSV-G |
S.C. injection of LV in HHD mice; or boost with peptide/IFA |
potent and diversified CTLs, secreting IFN-γ |
Yes |
(86) |