Table 1.
Performance comparison of single domain SemiSVR, SVR and PWM on 23 PDZ domains in leave two domain–peptide interactions out cross-validation testing
| PDZ domain | SemiSVR | SVR | PWM |
|---|---|---|---|
| CHAPSYN-110_2/3 | 0.75 | 0.57 | 0.71 |
| CHAPSYN-110_3/3 | 0.86 | 0.60 | 0.79 |
| GM1582_2/3 | 0.74 | 0.64 | 0.68 |
| HTRA3_1/1 | 0.73 | 0.66 | 0.70 |
| LIN7C_1/1 | 0.89 | 0.59 | 0.76 |
| MAGI-2_2/6 | 0.85 | 0.55 | 0.73 |
| MAGI-2_6/6 | 0.71 | 0.67 | 0.69 |
| MAGI-3_1/5 | 0.71 | 0.49 | 0.64 |
| MALS2_1/1 | 0.55 | 0.40 | 0.60 |
| OMP25_1/1 | 0.77 | 0.63 | 0.65 |
| PDZK3_1/1 | 0.78 | 0.64 | 0.70 |
| PDZ-RGS3_1/1 | 0.82 | 0.80 | 0.68 |
| PSD95_2/3 | 0.69 | 0.37 | 0.65 |
| PSD95_3/3 | 0.82 | 0.70 | 0.80 |
| PTP-BL_2/5 | 0.83 | 0.60 | 0.77 |
| SAP102_2/3 | 0.81 | 0.63 | 0.66 |
| SAP97_1/3 | 0.74 | 0.57 | 0.69 |
| SAP97_2/3 | 0.74 | 0.50 | 0.71 |
| SCRB1_3/4 | 0.84 | 0.59 | 0.75 |
| SHANK1_1/1 | 0.91 | 0.88 | 0.81 |
| SHANK3_1/1 | 0.88 | 0.82 | 0.80 |
| G1-SYNTROPHIN_1/1 | 0.87 | 0.58 | 0.79 |
| ZO-1_1/3 | 0.75 | 0.51 | 0.75 |
| Average Performance | 0.79 | 0.61 | 0.72 |
Numbers indicate the average percentage of correct predictions. Bold numbers indicate the best performance.