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(A–D) The degrading effects of CM-1 on pre-miRNA mimics. Left panels show predicted stem-loop formation of pre-miRNA mimics obtained from miRBase database (http://www.mirbase.org). Right panels, following CM-1 or RNase If treatment, the distribution of substrates (pre-miRNA mimics) and their degradation products were resolved by polyacrylamide-urea gel electrophoresis and visualized by silver staining. All data are representative of three independent experiments.
