Table 1.
Potency (pD2) and intrinsic activity (Emax) for salbutamol-induced smooth muscle relaxation after treatment with rosiglitazone
| pD2 (−log [mol·L−1]) | Emax (g) | |
|---|---|---|
| Ctrl | 6.69 ± 0.09 | 1.13 ± 0.04 |
| Des | 6.37 ± 0.15 | 0.87 ± 0.06** |
| Des + Rgz | 6.70 ± 0.12 | 1.03 ± 0.05# |
| Rgz | 6.71 ± 0.14 | 1.12 ± 0.06 |
Values (means ± standard error of the mean, SEM) were determined from the concentration–response data in Figure 2A. Results are average of five to eight separate experiments for each treatment group.
**
P < 0.01 (compared with the control group)
#
P < 0.05 (compared with the desensitized group).
Ctrl, control (vehicle alone); Des, desensitized; Rgz, rosiglitazone; pD2, molar concentration exerting half maximal effect; Emax, maximal effect.