Table 2.
Potency (pD2) and intrinsic activity (Emax) for salbutamol-induced tracheal smooth muscle relaxation after treatment with GW1929
| pD2 (−log [mol·L−1]) | Emax (g) | |
|---|---|---|
| Ctrl | 6.79 ± 0.20 | 0.96 ± 0.07 |
| Des | 6.68 ± 0.25 | 0.71 ± 0.06* |
| Des + GW1929 | 6.72 ± 0.16 | 0.93 ± 0.05# |
| GW1929 | 6.74 ± 0.10 | 0.99 ± 0.04 |
Values (means ± standard error of the mean, SEM) were determined from the concentration–response data in Figure 2B. Results are average of five separate experiments for each treatment group.
*
P < 0.05 (compared with the control group)
#
P < 0.05 (compared with the desensitized group).
Ctrl, control (vehicle alone); Des, desensitized; pD2, molar concentration exerting half maximal effect; Emax, maximal effect.