Figure 6.

Effects of CB₂ agonist AM1241 on the CFA model of inflammatory pain in rats. (A) Effects of AM1241 on thermal hyperalgesia (▴ ipsilateral paw, • contralateral paw) following systemic i.p. administration. (B) Effects of AM1241 on thermal hyperalgesia following i.DRG or i.t. administration (100 nmol·rat⁻¹). Responses of only the ipsilateral paws of the treated animals were shown. Responses of the respective contralateral paws of all treatment groups are similar to that of the vehicle treated contralateral paws (not shown). (C) Effects of AM1241 on thermal hyperalgesia (▴ ipsilateral paw, • contralateral paw) following the hindpaw ipsilateral or contralateral injection (i.paw). Data represent mean ± SEM (n = 6–8). *P < 0.05; **P < 0.01 as compared with vehicle-treated animals; ++P < 0.01 as compared with ipsilateral paw injection.