Figure 7.

Effects of CB₂ agonist AM1241 on mechanical allodynia in the SNL model of neuropathic pain in rats. (A) AM1241 dose-dependently attenuated mechanical allodynia. One to two weeks following spinal nerve injury, A-836339 was injected 30 min before testing. Data expressed as mean ± SEM (n = 6). *P < 0.05, **P < 0.01 as compared with vehicle-treated animals. (B) Effects of AM1241 on mechanical allodynia following i.DRG and i.t. administration. Data represent mean ± SEM (n = 7–8). *P < 0.05; **P < 0.01 as compared with vehicle-treated animals. (C) Lack of naloxone blockade of AM1241 (30 µmol·kg⁻¹ i.p.) reversal of mechanical allodynia. Data represent mean ± SEM (n = 6). **P < 0.01 vs. vehicle-treated animals. Responses of only the ipsilateral paws of the treated animals were shown. Responses of the respective contralateral paws of all treatment groups are similar to that of the vehicle treated contralateral paws (not shown).