Figure 4.

Effect of edelfosine on recombinant SK3/K_Ca2.3 channel and IK_Ca channel. (A) Left: Example of recombinant SK3 whole-cell K⁺ currents, recorded in one cell, obtained in control condition or after acute application of 1 µM edelfosine or 10 nM apamin (pCa = 6). Right: SK3 current obtained at 0 mV from voltage ramps (left) as a function of time. The cell was exposed to 1 µM edelfosine or 10 nM apamin as indicated by the arrows. (B) Left: Example of recombinant IK_Ca whole-cell K⁺ currents, recorded in one cell, obtained in control conditions or after acute application of 1 µM edelfosine or 1 µM clotrimazole (pCa = 6). Right: IK_Ca current obtained at 0 mV from voltage ramps (left) as a function of time. The cell was exposed to 1 µM edelfosine or 1 µM clotrimazole as indicated by the arrows.