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Patterns of gene mutations and amplifications in melanoma.
| Melanoma Subtype | BRAF Mutation | NRAS Mutation | c-KIT Mutation | c-KIT Amplification | GNαQ Mutation |
|---|---|---|---|---|---|
| Sun-exposed Cutaneous (CM) | 43% | 26% | Non-CSD: < 2% CSD: 2–17% |
Non-CSD: 0–7% CSD: 6% |
< 1% |
| Acral (ALM) | 18% | 4% | 18% | 24% | < 1% |
| Mucosal (MuM) | 6% | 14% | 24% | 26% | < 1% |
| Uveal (UvM) | < 1% | < 1% | < 1% | < 1% | 45% |
The table shows the prevalence of the listed genetic events in melanoma clinical specimens. CSD, chronic-sun damaged
