Table 1.
Genes from which SNPs were chosen for analyses.
Gene | Location | SNPs | Role in Dopamine (DA) |
---|---|---|---|
DRD3 | 3q13.3 | 32 | codes D3 subtype of DA receptors |
SLC6A3 (a.k.a. DAT1) | 5p15.3 | 35 | DA transporter that mediates reuptake of DA from the synapse |
DRD1 | 5q35.1 | 9 | codes D1 subtype of DA receptors |
DDC | 7p12.2 | 81 | codes a protein that converts L-DOPA to DA |
DBH | 9q34 | 37 | converts DA to norepinephrine |
DRD4 | 11p15.5 | 4 | codes D4 subtype of DA receptors |
DRD2 | 11q23 | 40 | codes D2 subtype of DA receptors |
COMT | 22q11.21 | 35 | affects degradation of catecholamines (including DA) |
Note. Location = chromosome location of the gene; SNPs = number of single nucleotide polymorphisms in that gene available in the SAGE data from the Illumina Human IM Bead Chip following quality control procedures; DRD3 = dopamine receptor D3; SLC6A3 = solute carrier family 6 (DAT1 = dopamine transporter 1); DRD1 = dopamine receptor D1; DDC = dopa decarboxylase; DBH = dopamine beta-hydroxylase; DRD4 = dopamine receptor D4; DRD2 = dopamine receptor D2; COMT = catechol-O-methyltransferase; L-DOPA = L-3,4-dihydroxyphenylalanine.