Table 2.

SNPs significantly associated with sensation seeking (p < 0.05 and FDR < 0.10) from individual SNP tests.

SNP	Gene	Chr	Pos (bp)	Function	Allele	MAF	B	Z	p	FDR
rs11575551	DDC	7	50,493,757	UTR-3’	C	0.03	−3.266	−2.756	0.006	0.006
rs11575522	DDC	7	50,502,889	Intron	A	0.05	−2.185	−2.581	0.010	0.013
rs11575542	DDC	7	50,498,481	Missense	A	0.05	−2.125	−2.512	0.012	0.019
rs11575543	DDC	7	50,498,363	Intron	T	0.05	−2.170	−2.506	0.012	0.025
rs3829897	DDC	7	50,597,258	Intron	T	0.42	−0.896	−2.456	0.014	0.031
rs7876027	DBH	9	135,504,360	Intron	G	0.07	1.688	2.335	0.020	0.038
rs174699	COMT	22	18,334,458	Intron	C	0.06	−1.748	−2.290	0.022	0.044
rs10278338	DDC	7	50,597,764	Intron	T	0.34	−0.842	−2.277	0.023	0.050
rs11575552	DDC	7	50,493,740	UTR-3’	C	0.02	−3.118	−2.250	0.024	0.056
rs933271	COMT	22	18,311,407	Intron	C	0.32	−0.827	−2.127	0.033	0.063
rs12669770	DDC	7	50,597,382	Intron	A	0.33	−0.732	−1.984	0.047	0.069
rs2975284	SLC6A3	5	1,485,552	Intron	T	0.01	−2.902	−1.970	0.049	0.075

Note. SNP = single nucleotide polymorphism in the regression equation; Gene = gene location of the SNP (see Table 1 for gene function descriptions); Chr = chromosome location of the SNP; Pos (bp) = position on the chromosome (in base pairs) of the SNP; Function = SNP function; UTR-3’ = SNP located in an untranslated region (UTR) at the 3’ end of the gene that may affect the stability, localization, and/or efficiency of messenger RNA (mRNA) translation of the gene; Intron = non-coding SNP; Missense = missense mutation, in which each allele produces a different amino acid; Allele = minor allele (i.e. less frequent nucleotide) for which the regression effect, B, is reported; MAF = minor allele frequency; B = regression coefficient for the effect of the SNP; Z = z-score for the regression coefficient (calculated as B / std.error(B)); p = two-tailed p-value for B; FDR = False Discovery Rate (see Equation 1 in text).