Fig. 3.

Increased glycolysis and decreased glucose oxidation in monocrotaline-induced RVH are reversed by the inhibition of pyruvate dehydrogenase kinase (PDK) by dichloroacetate (DCA; adapted from [9]). a RV O₂ consumption measured by high-resolution respirometry is reduced in RVH and DCA increases it. b, c Glucose uptake measured by FDG tracking and glucose transport evaluated by Glut1 immunostaining are increased in RVH and both are reduced by DCA. d Increased protein expression of Glut1 in RVH is decreased by DCA. e The increased phosphorylation of pyruvate dehydrogenase by PDK in RVH is reduced by DCA treatment