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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Cell Immunol. 2010 Nov 6;266(2):111–115. doi: 10.1016/j.cellimm.2010.10.009

Figure 3.

Figure 3

ROCK inhibition protects from the development of diabetes in NOD mice. A. Diabetes incidence in NOD mice (red line) (n=13) and NOD mice treated with Fasudil (black line) (n=12) for 12 weeks starting at 10 wks of age. Onset was determined after two consecutive readings of blood glucose levels >250mg/dl. *P≤0.0003 by Log-rank test. B. Evaluation of insulitis by hematoxylin/eosin staining of pancreata of NOD mice and NOD mice treated with Fasudil for 12 weeks starting at 10 wks of age. Representative photomicrographs showing differences in islet size and number are shown (magnification 40X and 200X, as indicated).