Table 7.
Hazard ratios for hospital admission and death due to thromboembolism* by combinations of covariates composing CHA2DS2-VASc scores 1 and 2
| Score and covariates | 1 year’s follow-up | 5 years’ follow-up | 10 years’ follow-up | |||||
|---|---|---|---|---|---|---|---|---|
| Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | |||
| CHA2DS2-VASc score=0 | 1.00 | 1.00 | 1.00 | |||||
| CHA2DS2-VASc score=1: | ||||||||
| Heart failure | 1.92 (0.47 to 7.91) | 0.37 | 3.39 (1.84 to 6.26) | <0.0001 | 2.69 (1.47 to 4.95) | 0.001 | ||
| Hypertension | 2.76 (1.70 to 4.48) | <0.0001 | 2.32 (1.75 to 3.07) | <0.0001 | 2.26 (1.75 to 2.92) | <0.0001 | ||
| Diabetes mellitus | 4.46 (2.01 to 9.89) | 0.0002 | 3.31 (2.00 to 5.46) | <0.0001 | 3.03 (1.89 to 4.86) | <0.0001 | ||
| Vascular disease | 0.97 (0.30 to 3.11) | 0.96 | 2.04 (1.29 to 3.22) | 0.002 | 2.22 (1.49 to 3.30) | <0.0001 | ||
| Age 65-74 | 3.68 (2.54 to 5.34) | <0.0001 | 3.07 (2.48 to 3.80) | <0.0001 | 3.12 (2.57 to 3.78) | <0.0001 | ||
| Female sex | 1.60 (1.02 to 2.49) | 0.04 | 1.25 (0.96 to 1.63) | 0.10 | 1.24 (0.98 to 1.57) | 0.08 | ||
| CHA2DS2-VASc score=2: | ||||||||
| Diabetes + heart failure | 5.80 (0.80 to 42.09) | 0.08 | 5.13 (1.64 to 16.07) | 0.005 | 5.79 (2.15 to 15.59) | 0.0005 | ||
| Diabetes + hypertension | 4.23 (1.68 to 10.65) | 0.002 | 2.58 (1.32 to 5.05) | 0.006 | 2.90 (1.62 to 5.21) | 0.0003 | ||
| Diabetes + age 65-74 | 1.89 (0.59 to 6.09) | 0.29 | 2.75 (1.56 to 4.85) | 0.0005 | 2.94 (1.77 to 4.90) | <0.0001 | ||
| Diabetes + vascular disease | – | 0.98 | 1.54 (0.22 to 10.98) | 0.67 | 2.69 (0.67 to 10.82) | 0.16 | ||
| Diabetes + female sex | 1.42 (0.20 to 10.30) | 0.73 | 0.90 (0.22 to 3.64) | 0.88 | 1.86 (0.76 to 4.51) | 0.17 | ||
| Heart failure + hypertension | 5.26 (2.37 to 11.66) | <0.0001 | 4.56 (2.76 to 7.53) | <0.0001 | 4.19 (2.62 to 6.72) | <0.0001 | ||
| Heart failure + age 65-74 | 2.33 (0.84 to 6.47) | 0.11 | 3.55 (2.15 to 5.86) | <0.0001 | 3.65 (2.30 to 5.78) | <0.0001 | ||
| Heart failure + vascular disease | 4.55 (0.63 to 33.02) | 0.13 | 2.78 (0.69 to 11.22) | 0.15 | 2.26 (0.56 to 9.09) | 0.25 | ||
| Heart failure + female sex | – | 0.97 | 0.79 (0.11 to 5.67) | 0.82 | 1.32 (0.33 to 5.32) | 0.70 | ||
| Hypertension + age 65-74 | 3.26 (2.02 to 5.25) | <0.0001 | 3.21 (2.45 to 4.20) | <0.0001 | 3.44 (2.71 to 4.37) | <0.0001 | ||
| Hypertension + vascular disease | 2.02 (0.86 to 4.73) | 0.11 | 2.14 (1.35 to 3.42) | 0.001 | 2.28 (1.50 to 3.46) | 0.0001 | ||
| Hypertension + female sex | 2.37 (1.30 to 4.32) | 0.005 | 2.15 (1.52 to 3.04) | <0.0001 | 2.16 (1.58 to 2.95) | <0.0001 | ||
| Age 65-74 + vascular disease | 3.70 (2.03 to 6.74) | <0.0001 | 3.56 (2.52 to 5.02) | <0.0001 | 3.80 (2.79 to 5.18) | <0.0001 | ||
| Age 65-74 + female sex | 3.61 (2.46 to 5.28) | <0.0001 | 3.04 (2.44 to 3.79) | <0.0001 | 3.11 (2.55 to 3.78) | <0.0001 | ||
| Vascular disease + female sex | 3.69 (1.15 to 11.88) | 0.03 | 2.81 (1.32 to 5.99) | 0.008 | 3.38 (1.79 to 6.38) | 0.0002 | ||
| Age≥75 | 5.96 (4.32 to 8.23) | <0.0001 | 6.16 (5.14 to 7.38) | <0.0001 | 6.21 (5.27 to 7.33) | <0.0001 | ||
| Previous thromboembolism | 20.44 (13.23 to 31.57) | <0.0001 | 11.27 (8.37 to 15.18) | <0.0001 | 10.44 (7.91 to 13.78) | <0.0001 | ||
Results from Cox proportional-hazard analyses; CHA2DS2-VASc score=0 was reference.
*Includes peripheral artery embolism, ischaemic stroke, and pulmonary embolism.